RIFAMYCIN SV
- Product Name
- RIFAMYCIN SV
- CAS No.
- 6998-60-3
- Chemical Name
- RIFAMYCIN SV
- Synonyms
- rifocyn;rifocin;rifamicinesv;RIFAMYCIN SV;RIFAMYCIN INN;Rifamycin S-Na;Rifamycin (9CI);RIFAMYCIN SV USP/EP/BP;Rifaximin EP Impurity C;Rifaximin impurity C (EP)
- CBNumber
- CB2731058
- Molecular Formula
- C37H47NO12
- Formula Weight
- 697.77
- MOL File
- 6998-60-3.mol
RIFAMYCIN SV Property
- Melting point:
- 300° (dec 140°)
- alpha
- D20 -4° (methanol)
- Boiling point:
- 701.9°C (rough estimate)
- Density
- 1.2275 (rough estimate)
- refractive index
- 1.5350 (estimate)
- pka
- 5.17±0.70(Predicted)
Safety
- Toxicity
- LD50 in mice (mg/kg): 550 i.v.; 625 i.p.; 2120 orally (Bergamini, Fowst)
N-Bromosuccinimide Price
- Product number
- R509625
- Product name
- Rifogal
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- API0013235
- Product name
- RIFAMYCIN SV
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.32
- Updated
- 2021/12/16
- Product number
- API0013235
- Product name
- RIFAMYCIN SV
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $4960
- Updated
- 2021/12/16
- Product number
- 2841A
- Product name
- Rifamycin SV
- Packaging
- 10g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- 2841A
- Product name
- Rifamycin SV
- Packaging
- 100mg
- Price
- $40
- Updated
- 2021/12/16
RIFAMYCIN SV Chemical Properties,Usage,Production
Uses
Rifogal (Rifaximin EP Impurity C NA) is a antibacterial drug which functions by inhibiting bacterial RNA polymerase (RNAP), is an important part of the antibacteral armamentarium. Also, it is one of the few drugs in a multidrug regimens for treating lung disease (LD) due to Mycobacterium avium complex (MAC).
Definition
ChEBI: A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.
Pharmaceutical Applications
The simplest rifamycin in clinical use, obtained by elimination of a glycolic moiety from rifamycin B. Formulated as sodium salt for parenteral administration. Also available for topical use. Its activity, general properties and pharmacokinetics are very similar to those of rifamide. It is orally absorbed and excreted mainly in the bile. Intramuscular doses of 250 mg produce mean plasma levels of about 2 mg/L. The plasma half-life is around 2 h.
In addition to uses similar to those of rifamide, it is administered topically in surgery and has been proposed for the treatment of synovitis by intra-articular injections. A topical preparation is used for application to wounds and bedsores. Cases of anaphylactic reactions have been reported after local administration of the drug.
Purification Methods
Rifamycin SV gives yellow-orange crystals from Et2O/pet ether or aqueous EtOH, is very soluble in MeOH, EtOH, Me2CO and EtOAc, and is less soluble in Et2O and HCO3-, but slightly soluble in H2O and pet ether. Its UV has max at 223, 314 and 445nm ( 1cm 586, 322 and 204) in phosphatebuffer pH 7. [NMR: Bergamini & Fowst Arzneim.-Forsch 15 951 1965.]
RIFAMYCIN SV Preparation Products And Raw materials
Raw materials
Preparation Products
RIFAMYCIN SV Suppliers
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- 16314854226
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- United States
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- United States
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View Lastest Price from RIFAMYCIN SV manufacturers
- Product
- RIFAMYCIN SV 6998-60-3
- Price
- US $17.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-01-06
- Product
- RIFAMYCIN SV 6998-60-3
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-07
- Product
- RIFAMYCIN 6998-60-3
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-18